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C.A. Bruggeman, H.W. Doerr, A. Ramon, M. Scholz's Novel Immunological Aspects of CMV-Related Diseases: PDF

By C.A. Bruggeman, H.W. Doerr, A. Ramon, M. Scholz

ISBN-10: 380557049X

ISBN-13: 9783805570497

Exact subject factor: Intervirology 1999, Vol. forty two, No. 5-6 This distinctive factor comprises contributions via major scientists and clinicians within the box of CMV, who participated within the second Symposium on CMV-Related Immunopathology, held in Maastricht, Netherlands, in September 1999. contemporary study has proven that cytomegalovirus manipulates the immune procedure in an evidently 'intelligent' approach to advertise virus endurance, replication and dissemination. This manipulation ends up in aberrant host immune responses and to ailment in immunocompromised folks similar to transplant recipients or AIDS sufferers. notwithstanding, there's turning out to be proof that CMV-related immunopathomechanisms can also be of value in grownup non-immunocompromised humans, even within the absence of detectable viremia. Reflecting and analyzing the main updated details on hand on CMV-related immunopathology and anti-CMV treatment, this ebook might be of significant curiosity for clinicians taken with the prognosis and therapy of CMV infections in addition to for researchers engaged on herpesvirus biology and the improvement of antiviral medicines.

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Additional info for Novel Immunological Aspects of CMV-Related Diseases: Pathogenesis, Diagnosis and Therapy (Intervirology, 5-6)

Example text

21 Henry S: Induction of MCMV gene expression in latently infected macrophage progenitor cells by maturation stimuli (abstract). J Clin Virol 1999;12:98. 22 Mutimer D, Mirza D, Shaw K, O’Donnell K, Elias E: Enhanced (cytomegalovirus) viral replication associated with septic bacterial complications in liver transplant recipients. Transplantation 1997;63:1411–1415. 23 Kutza AS, Muhl E, Hackstien H, Kirchner H, Bein G: High incidence of active cytomegalovirus infection among septic patients. Clin Infect Dis 1998;26:1076–1082.

41 Mocarski ES, Kemble GW, Lyle JM, Greaves RF: A deletion mutant in the human cytomegalovirus gene encoding IE1(491aa) is replication defective due to a failure in autoregulation. Proc Natl Acad Sci USA 1996;93:11321– 11326. 42 Greaves RF, Mocarski ES: Defective growth correlates with reduced accumulation of a viral DNA replication protein after low-multiplicity infection by a human cytomegalovirus ie1 mutant. J Virol 1998;72:366–379. 43 Prösch S, Staak K, Stein J, Liebenthal C, Stamminger T, Volk HD, Krüger DH: Stimulation of the human cytomegalovirus IE enhancer/ promoter in HL-60 cells by TNF· is mediated via induction of NF-ÎB.

The ligand for receptors UL33 and UL78 are unknown. However, study of the murine [62] and rat [63] homologues of UL33 (M33 and R33, respectively) demonstrated that this protein plays a role in homing virus to salivary glands and establishment of viral latency at this site. Study of the rat homologue of UL78 shows that deletion of this protein significantly lowers viral replication in vitro, prolongs survival in vivo, and leads to the formation of syncytia [64]. In the context of the infected cell, US27 and US28 bind the CC chemokines, RANTES and MCP-1 with high affinity while US28 also binds MCP3 and MIP1· and ß [61].

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Novel Immunological Aspects of CMV-Related Diseases: Pathogenesis, Diagnosis and Therapy (Intervirology, 5-6) by C.A. Bruggeman, H.W. Doerr, A. Ramon, M. Scholz


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