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Download e-book for iPad: Cardiovascular Pharmacology: Heart and Circulation by Paul M. Vanhoutte (Eds.)

By Paul M. Vanhoutte (Eds.)

ISBN-10: 0123849039

ISBN-13: 9780123849038

Heart problems continues to be an enormous explanation for demise and incapacity in constructed international locations and, more and more so, within the constructing world. Presented during this quantity of Advances in Pharmacology are one of the most promising chances for treating huge numbers of people stricken with those conditionsThis quantity comprises updated experiences of an important rising cardiovascular remedies written by means of global leaders within the box.

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Additional info for Cardiovascular Pharmacology: Heart and Circulation

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2003). A new cardioprotective agent, JTV519, improves defective channel gating of ryanodine receptor in heart failure. American Journal of Physiology-Heart and Circulatory Physiology, 284(3), H1035–H1042. , Jones, P. , et al. (2008). Caffeine induces Ca2+ release by reducing the threshold for luminal Ca2+ activation of the ryanodine receptor. The Biochemical Journal, 414(3), 441–452. , Betzenhauser, M. , & Marks, A. R. (2010a). Ryanodine receptor studies using genetically engineered mice. FEBS Letters, 584(10), 1956–1965.

Although the mechanism involved in this process is still under investigation, results from trial ZS-01­ 206 indicate that short-term treatment with rhNRG-1 may not only increase the LVEF, but also inhibit and even reverse cardiac remodeling. These changes in cardiac structure might improve the long-term prognosis of CHF. While other stresses that might accelerate the development of CHF were controlled by standard CHF therapies, these treatments did not repair injured cardiac muscles. In contrast, rhNRG-1 treatment caused a 42 Xu et al.

Jones, J. , et al. (2010). 6, protein kinase A, and K201. Cardiovascular Research, 85 (1), 68–78 Brillantes, A. , et al. (1994). Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. Cell, 77(4), 513–523. Bristow, M. , et al. (1982). Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts. The New England Journal of Medicine, 307(4), 205–211. Campbell, D. , Giles, W. , Hume, J. , et al. (1988). Inactivation of calcium current in bull­ frog atrial myocytes.

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Cardiovascular Pharmacology: Heart and Circulation by Paul M. Vanhoutte (Eds.)


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