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Read e-book online Bisphosphonates and Tumor Osteolysis PDF

By H. Fleisch (auth.), Professor Dr. Kurt W. Brunner, Professor Dr. Herbert Fleisch, Professor Dr. Hans-Jörg Senn (eds.)

ISBN-10: 3642836682

ISBN-13: 9783642836688

ISBN-10: 3642836704

ISBN-13: 9783642836701

This quantity informs the reader approximately uncomplicated chemical and experimental features of the bisphosphonates, their software in neoplastic hypercalcemia, and the elemental results of those medications in neoplastic osteolysis. preliminary studies, which desire affirmation via higher randomized reports, additionally care for the long-term software and doubtless favorable impact of bisphosphonates in metastatic bone disorder. it's important for clinical oncologists and internists to maintain abreast of contemporary info during this new quarter of scientific melanoma study.

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Extra resources for Bisphosphonates and Tumor Osteolysis

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However, a single infusion of ClzMBP or APD delivered over a few hours seems to be as effective, at least in the short term, as daily injections repeated during 1 week. This observation does not mean that the maintenance of normocalcemia is not dependent upon the amount of bisphosphonate accumulated in the bone. However, the exact relationship between the bisphosphonate skeletal content and the duration of bone resorption inhibition is not known. As mentioned above a poor response to bisphosphonate therapy can be occasionally observed in adequately rehydrated patients.

22 H. Fleisch Fraser D, Russell RGG, Pohler 0, Robertson WG, Fleisch H (1972) The influence of disodium ethane-1-hydroxy-1,1-diphosphonate (EHDP) on the development of experimentally induced urinary stones in rats. ). Lancet 1: 799 Gallagher JA, Guenther HL, Fleisch H (1982) Rapid intracellular degradation of newly synthesized collagen by bone cells. Effect of dichloromethylenebisphosphonate. Biochim Biophys Acta 719: 349-355 Garattini S (1985) Bone resorption, metastasis, and diphosphonates. Monographs of the Mario Negri Institute for pharmacological research.

Note that a state of dehydration consecutive to hypercalcemia can lead to an increased renal reabsorption of both sodium and Ca. However, this mechanism 32 J. P. Bonjour and R. Rizzoli PARA THYROID GLANDS a -- / KIDNEY 1. 2~(OH>p'! OSTEOCLAST ---------. ~ INTESTINE ~ Tubular reabsorption of calcium ... of phosphate .... Intestinal absorption of calcium and phosphate ... Bone resorption ... 2. Similar influence of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) on kidney and bone target cells.

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Bisphosphonates and Tumor Osteolysis by H. Fleisch (auth.), Professor Dr. Kurt W. Brunner, Professor Dr. Herbert Fleisch, Professor Dr. Hans-Jörg Senn (eds.)

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