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Biochemical Actions of Hormones. Volume 5 - download pdf or read online

By Gerald Litwack (Eds.)

ISBN-10: 0124528058

ISBN-13: 9780124528055

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Extra info for Biochemical Actions of Hormones. Volume 5

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All these results are consistent with an increase in acetylation of adrenal histones after ACTH administration; the reduction in charge of the lysine residues would account for the changes in acid dye binding, and the release of associated DNA sequences would permit increased binding of AO. G. ALTERATIONS IN HISTONE ACETYLATION INDUCED BY DRUGS Drugs that influence RNA synthesis also modify the balance between histone acetylation and deacetylation. Following are three examples. (a) The administration of phénobarbital or 3-methylcholanthrene to rats leads to a marked elevation in the activity of the hepatic microsomal mixed 1.

Postsynthetic Modifications of Historie Primary Structure 39 lengths of chromatin from different sources (cf. Compton et al, 1976). , 1976). , 1976). , 1977) and certain higher eukaryotes (Thomas and Thompson, 1977). In Physarum, repeat lengths varying from 190 to 173 base pairs could be detected upon treatment of nuclei with staphylococcal nuclease for different lengths of time. , 1977). Despite significant evolutionary variability in sequences of certain his tones, little variability has been detected in DNA lengths of nucleosome monomers containing these histones.

Most of the increase in RNA synthesis occurs after the acetylation has peaked. F. PEPTIDE HORMONE E F F E C T S ON HISTONE ACETYLATION 1. , 1969). , 1969). 2. Insulin Stimulation of Histone Acetylation and RNA Synthesis in the Liver The broad spectrum of insulin effects on hepatocytes includes the induction of tyrosine aminotransferase by a mechanism requiring de novo RNA and protein synthesis (Wicks, 1969; Schimke and Doyle, 1970). Insulin has been found to stimulate both the acetylation and phosphorylation of liver 34 E.

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Biochemical Actions of Hormones. Volume 5 by Gerald Litwack (Eds.)

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