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Atlas of Fundus Autofluorscence Imaging - download pdf or read online

By Frank Holz, Richard Spaide, Alan C. Bird, Steffen Schmitz-Valckenberg (eds.)

ISBN-10: 3540719938

ISBN-13: 9783540719939

ISBN-10: 3540719946

ISBN-13: 9783540719946

During fresh years, FAF (Fundus autofluorescence) imaging has been proven to be precious in a variety of retinal illnesses in regards to diagnostics, documentation of alterations, identity of sickness development, and tracking of novel remedies. Hereby, FAF imaging offers more information above and past traditional imaging tools.
This distinct atlas presents a complete and updated evaluation of FAF imaging in retinal illnesses. It additionally compares FAF findings with different imaging innovations such as
fundus picture, fluorescein- and ICG angiography in addition to optical coherence tomography.
General ophthalmologists in addition to retina experts will locate this a truly priceless consultant which illustrates usual FAF features of varied retinal diseases.

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Extra info for Atlas of Fundus Autofluorscence Imaging

Example text

The FAF distribution roughly matches the distribution of rod photoreceptors [47], which is not surprising since LF derives from precursors within phagocytosed photoreceptor outer segments. What is surprising, however, is that the distribution does not reflect the narrow distribution of cones at the fovea. Instead, FAF imaging at 550 nm reveals a shallow minimum in autofluorescence with no systematic increase in the signal corresponding to the narrow cone distribution [34]. The rate of LF formation from cones may be slower, as suggested by the observation in Rhesus monkeys that the number of foveal cone-derived phagosomes in the RPE was only one-third of the number of extrafoveal rod-derived phagosomes [48].

There is no significant accumulation of the autofluorescent material within the retina unless a disease process exists that limits the RPE’s ability to phagocytose the outer segments [7, 8]. If the anatomic relationship between the photoreceptor outer segments and the RPE is intact, the intensity of autofluorescence states parallels the amount and distribution of lipofuscin [9–11]. In cases in which there is a functional or spatial perturbation of the photoreceptor outer segment–RPE relationship, additional fluorophores can accumulate that are not, strictly speaking, lipofuscin, which is an intracellular accumulation of indigestible material within lysosomes.

Delori, FC (1994) Spectrophotometer for noninvasive measurement of intrinsic fluorescence and reflectance of the ocular fundus. Applied Optics 33:7439–7452 Chapter 2 Origin of Fundus Autofluorescence 27 23. Delori, FC, Dorey, CK, Staurenghi, G et al. (1995) In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophthalmol Vis Sci 36:718–729 24. Wade, AR, Fitzke, FW (1998) A fast, robust pattern recognition system for low light level image registration and its application to retinal imaging.

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Atlas of Fundus Autofluorscence Imaging by Frank Holz, Richard Spaide, Alan C. Bird, Steffen Schmitz-Valckenberg (eds.)


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