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Antiviral research : strategies in antiviral drug discovery - download pdf or read online

By Robert L. LaFemina

ISBN-10: 1555814395

ISBN-13: 9781555814397

ISBN-10: 1555815499

ISBN-13: 9781555815493

Captures the country of the technology with twenty studies that research the newest in today’s antiviral drug discovery efforts.

  • Presents the elemental ideas of antiviral brokers and forecasts destiny possibilities.
  • Investigates novel enzyme and protein inhibitors.
  • Analyzes scientific facets of viral an infection in regards to therapy and toxicity.
  • Examines recognized and strength ambitions in any respect levels of viral improvement.
  • Serves as a source for virologists, biochemists, pharmaceutical chemists, and different investigators.
  • Covers a extensive diversity of viruses, together with HIV-1, HSV, and HCV.

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M. Coen. 2001. Linear diffusion on DNA despite high-affinity binding by a DNA polymerase processivity factor. Mol. Cell 8:911–920. 127. Reardon, J. E. 1989. Herpes simplex virus type 1 and human DNA polymerase interactions with 29-deoxyguanosine-59-triphosphate analogues. J. Biol. Chem. 264:19039–19044. 128. Reardon, J. , and T. Spector. 1989. Herpes simplex virus type 1 DNA polymerase. Mechanism of inhibition by acyclovir triphosphate. J. Biol. Chem. 264:7405–7411. 129. Reichman, R. , G. J. Badger, G.

F. Pass. 2007. Cytomegaloviruses, p. 2701–2772. In D. M. Knipe, P. M. Howley, D. E. Griffin, R. A. Lamb, M. A. Martin, B. Roizman, and S. E. ), Fields Virology, 5th ed. Lippincott Williams & Wilkins, Philadelphia, PA. 116. Moore, M. , F. M. Hamzeh, F. -H. Lee, and P. S. Lietman. 1994. Activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine against human cytomegalovirus when administered as single-bolus dose and continuous infusion in in vitro cell culture perfusion system. Antimicrob. Agents Chemother.

LaFemina ©2009 ASM Press, Washington, DC Chapter 2 Entry Inhibitors of Human Immunodeficiency Virus Masanori Baba Highly active antiretroviral therapy (HAART) based on the combination of different classes of inhibitors has dramatically improved the prognosis of human immunodeficiency virus type 1 (HIV-1) infection after its establishment (52, 109). In fact, more than 20 drugs, targeting reverse transcriptase and protease, are available in clinic for the treatment of HIV-1 infection. Since reverse transcriptase and protease are virus-specific enzymes, the emergence of drug-resistant viruses caused by amino acid mutations of the enzymes often results in treatment failure of HAART (36).

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Antiviral research : strategies in antiviral drug discovery by Robert L. LaFemina

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