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Antiviral Methods and Protocols (Methods in Molecular - download pdf or read online

By Derek Kinchington, Raymond F. Schinazi

ISBN-10: 0585235686

ISBN-13: 9780585235684

ISBN-10: 0896035611

ISBN-13: 9780896035614

Skilled scientists describe-in an easily-followed format-their state of the art options for comparing antiviral compounds. The assays defined contain structures for investigating medicines used opposed to herpesviruses, hepatitis viruses, human immunodeficiency viruses, human papillomaviruses, and influenza viruses. those well-tested tools variety from mobile assays to a few of the main updated molecular methods for deciding on compounds which are lively opposed to viral enzymes and the improvement of viral resistance opposed to medicines at the moment in use. well timed and entire, Antiviral equipment and Protocols bargains state-of-the-art researchers in academia, scientific departments, and the pharmaceutical the strong, reproducible, and novel tools had to overview compounds powerful opposed to either acute and protracted infections.

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Extra resources for Antiviral Methods and Protocols (Methods in Molecular Medicine)

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A notable example was the discovery of the pyran shown in Scheme 10. The X-ray crys- Page 8 Scheme 9 XM-323. Scheme 10 Pyran. tal structure of this compound complexed with the enzyme assisted further optimization (15). Another intriguing application of structural information in the development of better therapies has been in the characterization of resistance in both the HIV proteinase and HIV RT areas. The generation of resistance in HIV is thought to be owing to the poor fidelity of the RTleading to point mutations.

All accidents or incidents must be immediately reported to the laboratory director, medical evaluation provided, and written records maintained. 10. All cultures, stocks, and contaminated wastes must be decontaminated before disposal by an approved method, such as autoclaving. Materials to be decontaminated outside of the laboratory must be placed in a durable, leakproof container and closed for transport from the laboratory.

McKimm-Breschkin 367 30 Virological Methods for the Generation and Characterization of Influenza Viruses with Reduced Sensitivity to 4-Guanidino-Neu5Ac2en Jennifer L. McKimm-Breschkin, Anjali Sahasrabudhe, Tony J. Blick, Amanda J. Jowett, and Richard C. Bethell 375 Index 383 Page xi CONTRIBUTORS GRACIELA ANDREI Rega Institute for Medical Research, Katholieke Universiteit, Leuven, Belgium JANE ANGIER Glaxo-Wellcome Medicines Research Centre, Stevenage, UK JAN BALZARINI Rega Institute for Medical Research, Katholieke Universiteit, Leuven, Belgium RICHARD C.

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Antiviral Methods and Protocols (Methods in Molecular Medicine) by Derek Kinchington, Raymond F. Schinazi


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