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Antineoplastic and Immunosuppressive Agents Part I by C. Gordon Zubrod (auth.), Alan C. Sartorelli, David G. Johns PDF

By C. Gordon Zubrod (auth.), Alan C. Sartorelli, David G. Johns M. D. (eds.)

ISBN-10: 3642656781

ISBN-13: 9783642656781

ISBN-10: 3642656803

ISBN-13: 9783642656804

Over the previous twenty years a couple of makes an attempt were made, with various levels of luck, to gather in one treatise on hand details at the simple and utilized pharmacology and biochemical mechanism of motion of antineoplastic and immunosuppressive brokers. The logarithmic progress of information during this box has made it increasingly more tricky to do justice to all elements of this subject, and it truly is attainable that the current instruction manual, greater than 4 years in training, could be the final try and survey in a. unmarried quantity the whole box of substances em­ ployed in melanoma chemotherapy and immunosuppression. Even within the current example, it has proved priceless for functional purposes to post the fabric in components, even supposing the plan of the paintings constitutes, no less than within the editors' view, a unmarried built-in remedy of this examine quarter. a few components have contributed to the continual growth of study within the components of melanoma chemotherapy and immunosuppression. energetic compounds were rising at ever-increasing premiums from experimental tumor screening platforms maintained by means of numerous deepest and governmental laboratories via­ out the area. on the molecular point, wisdom of the modes of motion of estab­ lished brokers has persisted to extend, and has approved rational drug layout to playa considerably larger function in a procedure which, in its early years, depended nearly thoroughly upon empirical and fortuitous observations.

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Repeat day 42 Total 54 No. patients responding % Responding Ref. 2 33 WILSON and Loms (1965) 7 41 SULLIVAN et ai. (1967) 2 9 9 23 3 25 CONDIT et al. (1962) 4 10 1 7 Eastern Cooperative Group in Solid Tumor Chemotherapy (1967) ANDREWS and WILSON (1967) 5 9 MOERTEL et ai. (1970) inhibitor of DNA synthesis, which may act primarily as an inhibitor of DNA polymerase (FURTH and COHEN, 1968). , 1967) (Table 4). In cancer of the colon this drug has only been evaluated on a daily LV. push for 10 consecutive days schedule.

It is a direct and specific 26 A. GOLDIN et ai. : Table 3. Methotrexate in colon cancer evaluated by 8chedule Schedule I. O. No. patients evaluable 6 II. d. O. = 17 5 mg/day x 5 to 10 days. Repeat when toxicity allows or 5 mg/24 h continuous LV. Infusion x 5 to 10 days 22 (2) 50 mg/kg Q12h until toxicity or response Total 39 III. 5 to 10 mgfkg LV. Q2wks. IV. 2 mgfkg every other day x 4; repeat in 4 wks. ; repeat day 42 Total 54 No. patients responding % Responding Ref. 2 33 WILSON and Loms (1965) 7 41 SULLIVAN et ai.

Chemotherapy of cancer should be envisioned not as an isolated method of therapy, but in the context of its maximum contribution in the collaborative effort to eliminate all tumor cells from the patient with minimal side effects. : Clinical trials and combination chemotherapy. Cancer Chemother. Rep. 2, 81-97 (1971). : Cell kinetics and the chemotherapy of cancer. Cancer Chemother. Rep. 2, 23-33 (1971). : Evidence that drugs in mUltiple combinations have materially advanced the treatment of human malignancies.

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Antineoplastic and Immunosuppressive Agents Part I by C. Gordon Zubrod (auth.), Alan C. Sartorelli, David G. Johns M. D. (eds.)

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