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Download e-book for iPad: Advances in the Immunopathogenesis of Multiple Sclerosis by P. A. Muraro, A. Lugaresi, D. Gambi (auth.), D. Gambi, P. A.

By P. A. Muraro, A. Lugaresi, D. Gambi (auth.), D. Gambi, P. A. Muraro, A. Lugaresi, U. Ecari (eds.)

ISBN-10: 884700067X

ISBN-13: 9788847000674

ISBN-10: 884702269X

ISBN-13: 9788847022690

P.A. MURARO, A. LUGARESI, D. GAMBI a number of the pathological features of a number of sclerosis (MS) lesions were recognized for over a century. it is just lately, in spite of the fact that, that assorted styles of demyelination were associated with specific pathways of immune-mediated tissue destruction. specifically, the inter-individual heterogeneity of MS lesions has recommended that diversified mechanisms might act in numerous sufferers, accounting for the variety saw in scientific path, immunological findings in peripheral blood and cere­ brospinal fluid (CSF), and reaction to immunomodulatory remedies. to supply an outline of the fundamental mechanisms very likely eager about MS lesion initiation and improvement, a world assembly was once equipped within the context of the once a year Congress of the Italian Neuroimmunology organization (AINI), held on the college of Chieti, in Chieti Italy on 29 October 1998. The excessive ordinary of shows triggered us to document them in prolonged shape, to spotlight contemporary professional­ gress within the figuring out of uncomplicated mechanisms maintaining MS immuno­ pathogenesis. A critical position within the attainable mechanisms resulting in myelin destruc­ tion has been attributed to T lymphocytes reactive to myelin antigens. reviews at the myelin antigen-specific T mobile repertoire have contributed major advances to our wisdom of autoimmunity (Chapters 1,2).

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Extra resources for Advances in the Immunopathogenesis of Multiple Sclerosis

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J Neuroimmunol 23:125-132 Hickey WF (1991) Migration of hematogenous cells through the bloodbrain barrier and the initiation of CNS inflammation. Brain Pathol 1:97106 Tchelingerian J-L, Quinonero J, Booss J, Jacque C (1993) Localization of TNF-a. and IL-l~ immunoreactivities in striatal neurons after surgical injury to the hippocampus. Neuron 10:213-224 Neumann H, Schmidt H, Wilharm E, Behrens L, Wekerle H (1997) Interferon-y gene expression in sensory neurons: Evidence for autocrine gene regulation.

These data suggest that PAF is a mediator involved in the early phase of BBB damage but does not characterize the overall behavior of MS. Furthermore, these data explain the contradictory results in the literature regarding a role of PAF in MS and in experimental autoimmune encephalomyelitis [20-23]. In order to confirm that PAF appears concomitantly with the relapse of the disease, we have evaluated PAF levels in plasma and CSF and the number of gadolinium-enhancing lesions in two patients with RR MS at 50 M.

Brain Res 545:334-338 Ehrhard PB, Erb P, Graumann U, Otten U (1993) Expression of nerve growth factor and nerve growth factor receptor tyrosine kinase Trk in activated CD4-positive T cell clones. Proc Nat! Acad Sci USA 90:10984-10988 Elkabes S, DiCicco-Bloom EM, Black IB (1996) Brain microglial macrophages express neurotrophins that selectively regulate microglial proliferation and function. J Neurosci 16:2508-2521 Kerschensteiner M, Gallmeier E, Behrens L, Klinkert WEF, Kolbeck R, Hoppe E, Stadelmann C, Lassmann H, Wekerle H, Hohlfeld R (1999) Activated human T cells, B cells and monocytes produce brain-derived neurotrophic factor (BDNF) in vitro and in brain lesions: A neuroprotective role of inflammation?

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Advances in the Immunopathogenesis of Multiple Sclerosis by P. A. Muraro, A. Lugaresi, D. Gambi (auth.), D. Gambi, P. A. Muraro, A. Lugaresi, U. Ecari (eds.)

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