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Adenoviruses: Model and Vectors in Virus-Host Interactions: by M. Benkö, B. Harrach (auth.), Prof.Dr. Walter Doerfler, PDF

By M. Benkö, B. Harrach (auth.), Prof.Dr. Walter Doerfler, Petra Böhm (eds.)

ISBN-10: 3642055176

ISBN-13: 9783642055171

ISBN-10: 366205597X

ISBN-13: 9783662055977

After 3 volumes on adenoviruses in 1995 the earlier years have visible speedy development within the box of adenovirus study. in addition, adenoviruses have attracted huge curiosity as vectors in gene move regimens.

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Read or Download Adenoviruses: Model and Vectors in Virus-Host Interactions: Virion-Structure, Viral Replication and Host-Cell Interactions PDF

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Additional info for Adenoviruses: Model and Vectors in Virus-Host Interactions: Virion-Structure, Viral Replication and Host-Cell Interactions

Example text

This suggests that bases alone are able to attach to the plasma membrane, to interact with coated pits, to escape to cytoplasm and to attach to the nuclear membrane. 1999). In addition, the Ad7 penton base was shown to travel toward the cell nucleus, transducing plasmid DNA tethered to the base through a bivalent peptide that was able to attach simultaneously the base and DNA (BAL et al. 2000). It has been shown recently that a recombinant bacteriophage bearing Ad penton base in its capsid was able to internalize and transduce mammalian cells (DI GOVINE et al.

There are many things yet to be examined and confirmed. If the common origin with tectiviruses is true, are we going to discover an intermediate type of virus in the invertebrates? Have adenoviruses, because of the 30 M. BENKO and B. HARRACH complexity of their genome organization, an evolution pace which is in better harmony with that of the hosts? We hope that the presentation of the above data will increase awareness about the incredible heterogeneity of adenoviruses. This might stimulate further work on other subjects than HAdV-2 or 5, which would ultimately contribute to the recognition of new mechanisms used by the less sophisticated adenoviruses in their replication strategies.

1t has been suggested also that MHC-I alpha 2 chain might be a primary receptor for Ad5 (HONG et al. 1999). It has been shown that the integrins av/33 and av/35 are the secondary receptors for serotypes 2,3,4 and 12 (WICKHAM et al. 1993; BAI et al. 1993; MATHIAS et al. 1994). However, Ad40 and Ad41 lack the av/33 and av/35 ligand (RGD motif) in their bases; instead the Ad40 base carries RGAD, and Ad41 carries IGDD. Furthermore, the uptake of Ad41 in cells which are efficiently producing commonly used serotypes was shown to be delayed, suggesting that Ad41 entry might be independent of av integrins (ALBINSSON and KmD 1999).

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Adenoviruses: Model and Vectors in Virus-Host Interactions: Virion-Structure, Viral Replication and Host-Cell Interactions by M. Benkö, B. Harrach (auth.), Prof.Dr. Walter Doerfler, Petra Böhm (eds.)


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