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Read e-book online Activating and Inhibitory Immunoglobulin-like Receptors PDF

By Jeffrey V. Ravetch (auth.), Max D. Cooper M.D., Toshiyuki Takai Ph.D., Jeffrey V. Ravetch M.D., Ph.D. (eds.)

ISBN-10: 4431539409

ISBN-13: 9784431539407

ISBN-10: 4431679596

ISBN-13: 9784431679592

A extraordinary spectrum of novel immunoreceptors sharing similar immunoglobulin-like domain names and signaling capability has been pointed out lately. those receptors have attracted common curiosity simply because they resemble the TCR, BCR, and FcR complexes of their skill to function activating or inhibitory receptors at the cells that endure them. additionally, they're good situated to impact either innate and adaptive immunity. the complete diversity of ligands for those new receptor households continues to be no longer recognized, and figuring out in their physiological roles is much from whole. This quantity is the 1st try to summarize and spotlight all identified features of immunoglobulin-like receptors, offering a topical evaluation of the jobs and attribute positive aspects of the immunoglobulin-like receptors and comparable molecules within the immune approach. Researchers in immunology, molecular biology, telephone biology, scientific drugs, and pharmacology will locate this ebook invaluable.

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The first recognized mouse NK cell receptor with structural homology to human KIR was the ITIM-containing gp49B receptor. This receptor was originally identified on mouse mast cells (Arm et al. 1991; Caste lis et al. 1994) and is also expressed on IL-2 activated NK (LAK) cells (Rojo et al. 1997; Wang et al. 1997). However, in contrast to C3H-derived mast cells , IL-2-activated NK cells from C57BL/6 mice express alternative gp49 transcripts (Fig. I) . cDNA cloning revealed 6 different clones, clone 10 and II were missing exons 3 and 4, giving rise to truncated gp49A; clone 6 represented gp49A missing half of exon 4: clone 14 represented full length gp49B I .

Key words. Killer cell Ig-Iike receptor, Fcy receptor, T cell receptor, MHC class I, Cell surface receptor, Molecular recognition, Surface plasmon resonance Introduction There are a wide variety of immunoreceptors possessing immunoreceptor tyro sine-based inhibitory motifs (ITIMs) , which form what has been termed (Lanier 1998) the Inhibitory-receptor superfamily (IRS) . Molecules in the IRS fall into two groups, (I) immunoglobulin(Ig)-like receptors , and (2) C-type lectin-like receptors. Many of these IRS molecules have activatory counterparts that have almo st the same extracellular region s, but different intracellular regions .

1998), although increased FcaR expression in IgAN was also described in earlier reports (Kashem et al. 1994; Monteiro et al. 1995; Kashem et al. 1996; Kashem et al. 1997). Conversely, FcaR expression has been shown to be elevated on eosinophils of allergic individuals (Monteiro et al. 1993). Considering the expression patterns , analysis of regulatory mechanisms controlling FeaR gene expression in normal and pathogenic situations could provide the foundation for understanding the in vivo roles of this receptor.

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Activating and Inhibitory Immunoglobulin-like Receptors by Jeffrey V. Ravetch (auth.), Max D. Cooper M.D., Toshiyuki Takai Ph.D., Jeffrey V. Ravetch M.D., Ph.D. (eds.)

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