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Read e-book online 33rd Hemophilia Symposium: Hamburg 2002 PDF

By W. Schramm, H. Krebs (auth.), Professor Dr. med. Inge Scharrer, Professor Dr. med. Wolfgang Schramm (eds.)

ISBN-10: 3540009027

ISBN-13: 9783540009023

ISBN-10: 3642182607

ISBN-13: 9783642182600

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The discovery or emergence of new viruses heightens these concerns and requires extra vigilance to re-establish assurance on the safety of these products. Two new viruses serve as current examples. TT Virus (TTV) and first Generation Recombinant Factor VIII (rFVIII) Products When TTV was discovered in 1997 [2] and suggested to be associated with post-transfusion hepatitis, naturally patients, regulatory bodies and the plasma products industry were anxious. Further investigations found the virus to be of no clinical relevance, but revealed a high prevalence of TTV: low viral loads were found in up to 82% of plasma donations, and consequently in many plasma pools [3].

5 and Table 2. Factor VIII/IX activity activity up to 2% 45,37% 1823 activity over 2% 54,63% 2195 47,38% 334 52,62% 371 Hemophilia B Hemophilia A Fig. 3. Distribution of factor VIII/IX activity in patients with hemophilia A and B 0,40% 16 3,11% 125 Inhibitor No inhibitor 1,13% 8 1,70% 12 Low responder High responder 96,49% 3877 Hemophilia A 97,16% 685 Hemophilia B Fig. 4. Distribution of factor VIII/IX activity in patients with hemophilia A and B 6 W. Schramm, H. Krebs Ristocetin Cofactor above 30% 28,03% 851 Ristocetin Cofactor below 30% 71,97% 2185 Fig.

Blood 1995; 86: 1811–1819 Scandella D. Human anti-factor VIII antibodies: epitope localization and inhibitory function. Vox Sang 1996; 70 Suppl 1: 9–14 Healey JF, Lubin IM, Nakai H, Saenko EL, Hoyer LW, Scandella D, Lollar P. Residues 484–508 contain a major determinant of the inhibitory epitope in the A2 domain of human factor VIII. J Biol Chem 1995; 270: 14505–14509 Saenko EL, Ananyeva NM, Kouiavskaia DV, Khrenov AV, Anderson JA, Shima M, Qian J,Scott D. Haemophilia A: effects of inhibitory antibodies on factor VIII functional interactions and approaches to prevent their action.

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33rd Hemophilia Symposium: Hamburg 2002 by W. Schramm, H. Krebs (auth.), Professor Dr. med. Inge Scharrer, Professor Dr. med. Wolfgang Schramm (eds.)


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